Form: 8-K

Current report

January 7, 2026

 

Exhibit 99.2

 

Tumor HI EAP Patient Profiles

 

  Patient 1 Patient 2 Patient 3 Patient 4 Patient 5 Patient 6 Patient 7 Patient 8# Patient 9
Gender (M/F) / Age (Years) M / 55 F / 50 F / 50 F / 43 M / 74 M / 62 M / 74 M / 53 M / 24
Diagnosis Metastatic Insulinoma  Metastatic Insulinoma  Neuroendocrine Carcinoma of the Cervix  Metastatic Insulinoma  Metastatic Insulinoma  Metastatic Insulinoma 

Metastatic

Insulinoma 

Metastatic Proinsulinoma Metastatic Insulinoma 
# of Anti-hypoglycemic therapies at enrollment 2
Glucose Infusion Rate (GIR, mg/kg/min) at ersodetug initiation 6.0  

7.0 

(home TPN)

5.1  6.2  4.9  n/a (ambulatory) 5.6  Unknown amount 3.1 
Ersodetug Dose Regimen (dose/frequency) 6-9 mg/kg every 1-4 weeks 6-9 mg/kg every 1-2 weeks 9 mg/kg, every 1-2 weeks 9-12 mg/kg every 1-2 weeks 9 mg/kg every 1-3 weeks 9 mg/kg every 1-2 weeks 6-9 mg/kg every 1-2 weeks 9 mg/kg every 1-2 weeks 9 mg/kg every 1-3 weeks
Percent Reduction in GIR by 8 weeks of Ersodetug treatment (duration of Phase 3 upLIFT study) >50%, then 100% by 9 weeks <50% 100% 100% 100% n/a 100% Unknown amount 100%
Time to IV Glucose discontinuation (days) 74 139
(achieved 50% reduction)
4 5 2 n/a 3 n/a 42
Length of Hospitalization prior to ersodetug (days) 28 n/a (ambulatory) 15 49 34 n/a (ambulatory) 4 Unknown duration 16
# of Hospitalized Days in the 30-day period following ersodetug initiation 30 0 7 8 8 0 16 30 1
Baseline ECOG * 3
ECOG, Month 3 on ersodetug 0 5
Total Duration of ersodetug therapy (months) 13 5 5 14 22 (ongoing) 18 (ongoing) 6 1.5 10
Overall Survival (months) 14 5 5 14 22 (living) 18 (living) 6 1.5 10

 

# Patient was critically ill when treatment commenced and died of sepsis prior to determination of whether there was a therapeutic effect

 

*Eastern Cooperative Oncology Group (ECOG) Performance Status is a standardized measure of functional status ranging from 0 (fully active) to 5 (death), with increasing scores indicating greater disability and reduced ability to perform daily activities