November 23, 2020




Securities and Exchange Commission

Division of Corporation Finance

100 F. Street, N.E.

Washington, D.C. 20549


Re: Rezolute, Inc. (the "Company")

Registration Statement on Form S-3

File No. 333-250073


Ladies and Gentlemen:


In accordance with Rule 461 under the Securities Act of 1933, as amended, the undersigned respectfully requests that the effective date of the above-referenced Registration Statement be accelerated so that the same will become effective at 4:00 PM on November 27, 2020, or as soon thereafter as is practicable.


  Very truly yours,
  By: /s/ Keith Vendola
  Name:  Keith Vendola
  Title:    Chief Strategy Officer